Haugan et al: Rotigaptide Reverts Atrial Conduction Slowing Cell Communication and Adhesion
نویسندگان
چکیده
Ketil Haugan M.D. a, Anne Louise Kjølbye Ph.D. a, James K. Hennan, Ph.D. b, and Jørgen Søberg Petersen M.D., Ph.D., D.Sc. a , Zealand Pharma A/S, Smedeland 26B, DK-2600 Glostrup, Denmark. , Wyeth Research, Philadelphia, PA, USA * Correspondance and request for reprints: Ketil Haugan, Zealand Pharma A/S, Smedeland 26B, DK-2600 Glostrup, Denmark. Fax: +45 43281212. Phone: +45 43281263. E-mail: [email protected]
منابع مشابه
Gap junction-modifying antiarrhythmic peptides: therapeutic potential in atrial fibrillation
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245 Mechanism of arrhythmia in AF . . . . . . . . . . . . . . . . . . . . . . .246 Role of conduction slowing in AF . . . . . . . . . . . . . . . . . . . . .246 Gap junction dysfunction is associated with AF . . . . . . . . . ...
متن کاملModel-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs.
BACKGROUND Abnormal intercellular communication caused by connexin dysfunction may be involved in atrial fibrillation (AF). The present study assessed the effect of the gap junctional conduction-enhancing peptide rotigaptide on AF maintenance in substrates that result from congestive heart failure induced by 2-week ventricular tachypacing (240 bpm), atrial tachypacing (ATP; 400 bpm for 3 to 6 w...
متن کاملPharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.
Existing anti-arrhythmic therapy is hampered by lack of efficacy and unacceptable side effects. Thus, ventricular tachycardia and fibrillation remains the strongest predictor of in-hospital mortality in patients with myocardial infarction. In atrial fibrillation, rhythm control with conventional ion channel blockers provide no therapeutic benefit relative to rate control. Several lines of resea...
متن کاملEnhancement of ventricular gap-junction coupling by rotigaptide.
AIMS Rotigaptide is proposed to exert its anti-arrhythmic effects by improving myocardial gap-junction communication. To directly investigate the mechanisms of rotigaptide action, we treated cultured neonatal murine ventricular cardiomyocytes with clinical pharmacological doses of rotigaptide and directly determined its effects on gap-junctional currents. METHODS AND RESULTS Neonatal murine v...
متن کاملThe antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress.
OBJECTIVE As atrial conduction slowing is important in the pathogenesis of atrial reentry arrhythmias, a drug that increases atrial conduction or prevents atrial conduction slowing could serve to prevent atrial reentry arrhythmias. In this study, we investigated whether the novel stable antiarrhythmic peptide analog, ZP123, was able to prevent atrial conduction slowing. METHODS We examined th...
متن کامل